Although there is no evidence that they will do you any harm in the usual doses, megadoses have been reported to have side effects and actually decrease optimum physical performance.
But a 2004 report suggests that taking megadoses of vitamin E may actually do more harm than good.
Although the study results suggest that vitamin C may have a protective effect, it does not present conclusive evidence, nor do the researchers recommend megadoses of vitamin C to reduce heart disease risk.