prefix — Grammar. an affix placed before a word, base, or another prefix to modify a term's meaning, as by making the term negative, as un- in unkind, by signaling repetition, as re- in reinvent, or by indicating support, as pro- in proabolition. Compatible prefixes can work together, as un- and re- in unrefundable.
Four-or-more syllable rhymes
analgesic — An analgesic drug reduces the effect of pain.