amnesia — If someone is suffering from amnesia, they have lost their memory.
maniac — Mathematical Analyzer, Numerical Integrator and Computer
Four-or-more syllable rhymes
insomniac — a person who suffers from insomnia, the inability, especially when chronic, to obtain sufficient sleep, through difficulty in falling or staying asleep: Her husband, an insomniac, had at last fallen asleep at the computer, head resting on the keyboard.
oblivious — unmindful; unconscious; unaware (usually followed by of or to): She was oblivious of his admiration.
Four-or-more syllable rhymes
aphrodisiac — An aphrodisiac is a food, drink, or drug which is said to make people want to have sex.